InhaltsangabePreface. 1. Stumbling on Galectins (Samuel H. Barondes). 2. Galectins and their Functions in Plain Language (Anatole A. Klyosov). 3. Understanding Galectin Structure-Function Relationships to Design Effective Antagonists (Irina V. Nesmelova, Ruud P.M. Dings and Kevin H. Mayo). 4. Galectins as Regulators of Tumor Growth and Invasion by Targeting Distinct Cell Surface Glycans and Implications for Drug Design (Hans-J. Gabius and Albert M. Wu). 5. Nuclear and Cytoplasmic Localization of Galectin-1 and Galectin-3 and their Roles in pre-mRNA Splicing (John L. Wang, Kevin C. Haudek, Patricia G. Voss and Ronald J. Patterson). 6. Galectins in Regulation of Inflammation and Immunity (Fu-Tong Liu, Daniel K. Hsu, Ri-Yao Yang, Huan-Yuan Chen and Jun Saegusa). 7. Galectins as Danger Signals in Host-Pathogen and Host-Tumor Interactions: New Members of the Growing Group of "Alarmins" (Sachiko Sato and Gabriel Rabinovich). 8. The Role of Galectins in Organ Fibrosis (Neil C. Henderson and Tariq Sethi). 9. Galectin1, Cancer Cell Migration, Angiogenesis and Chemoresistance (Florence Lefranc, Marie Le Mercier, Véronique Mathieu and Robert Kiss). 10. Galectin3 in the Progression and Metastasis of Colorectal Neoplasia (James C. Byrd and Robert S. Bresalier). 11. Galectins in Malignant Gliomas: Expression, Functions and Possible Therapeutic Options (Herwig M. Strik and Anna Hoffman). 12. FoodRelated Carbohydrate Ligands for Galectins (Valeri V. Mossine, Vladislav V. Glinsky and Thomas P. Mawhinney). Index.

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Anatole A. Klyosov, PhD, is Chief Scientist and cofounder of Pro-Pharma-ceuticals, Inc. He has published more than 290 peer-reviewed articles in scientific journals; authored and edited books on enzymes, carbohydrates, and biotechnology, including Wood-Plastic Composites (Wiley); and holds thirty-nine patents.

Zbigniew J. Witczak, PhD, has extensive industrial and academic experience in carbohydrates. He has published more than ninety research papers and holds six patents in the fields of carbohydrate, medicinal, and biological chemistry. In 2000, Dr. Witczak was awarded the Melville L. Wolfrom Award of the ACS Division of Carbohydrate Chemistry for his outstanding research contribution to carbohydrate chemistry and service to the division.

David Platt, PhD, is Chief Executive Officer and cofounder of Pro-Pharmaceuticals, Inc. He has published peer-reviewed articles and holds many patents, primarily in the field of carbohydrate chemistry. Dr. Klyosov, Dr. Witczak, and Dr. Platt coedited the ACS symposium book Carbohydrate Drug Design.

Leseprobe

Preface. 1. Stumbling on Galectins (Samuel H. Barondes). 2. Galectins and their Functions in Plain Language (Anatole A. Klyosov). 3. Understanding Galectin Structure-Function Relationships to Design Effective Antagonists (Irina V. Nesmelova, Ruud P.M. Dings and Kevin H. Mayo). 4. Galectins as Regulators of Tumor Growth and Invasion by Targeting Distinct Cell Surface Glycans and Implications for Drug Design (Hans-J. Gabius and Albert M. Wu). 5. Nuclear and Cytoplasmic Localization of Galectin-1 and Galectin-3 and their Roles in pre-mRNA Splicing (John L. Wang, Kevin C. Haudek, Patricia G. Voss and Ronald J. Patterson). 6. Galectins in Regulation of Inflammation and Immunity (Fu-Tong Liu, Daniel K. Hsu, Ri-Yao Yang, Huan-Yuan Chen and Jun Saegusa). 7. Galectins as Danger Signals in Host-Pathogen and Host-Tumor Interactions: New Members of the Growing Group of "Alarmins" (Sachiko Sato and Gabriel Rabinovich). 8. The Role of Galectins in Organ Fibrosis (Neil C. Henderson and Tariq Sethi). 9. Galectin-1, Cancer Cell Migration, Angiogenesis and Chemoresistance (Florence Lefranc, Marie Le Mercier, Veronique Mathieu and Robert Kiss). 10. Galectin-3 in the Progression and Metastasis of Colorectal Neoplasia (James C. Byrd and Robert S. Bresalier). 11. Galectins in Malignant Gliomas: Expression, Functions and Possible Therapeutic Options (Herwig M. Strik and Anna Hoffman). 12. Food-Related Carbohydrate Ligands for Galectins (Valeri V. Mossine, Vladislav V. Glinsky and Thomas P. Mawhinney). Index.