Preeclampsia is a serious multisystem complication of late pregnancy with adverse effects for mothers and babies. Currently this disorder is diagnosed from clinical observations occurring late in the disease process. Unknown factors in the maternal circulation, possibly released by the preeclamptic placenta, have been linked to the pathophysiological changes characteristic of the disorder. The research described here used proteomic techniques to identify putative preeclampsia biomarkers from two sources: secreted from a placental cell line undergoing differentiation, and directly sampled from the serum and plasma of women with late-onset preeclampsia. The differentially regulated proteins found here provide an important first step towards developing effective biomarkers for diagnosing and/or predicting preeclampsia.

Hersteller:
Books on Demand GmbH
bod@bod.de
In de Tarpen 42
DE 22848 Norderstedt

Kelly Atkinson is a scientist specialising in protein biochemistry and human health research. She received bachelor''s and master''s degrees from the University of Arizona before studying biomarkers at the University of Auckland with the SCOPE Pregnancy Research Study. She currently works at Plant & Food Research in Auckland, New Zealand.