The book contains in its first part reviews on modelling of enzyme properties in organic solvents, lipase-catalysed synthesis of carboxylic amides, chemoenzymatic synthesis of lipidated peptides and chemoenzymatic transformations in nucleoside chemistry. In the second part contributions on recent developments in biocatalysis are given: lipase and esterase catalysed resolutions, investigations on regio- and stereoselective biocatalytic acylations in steroid side-chains and of substrate- and stereospecificity of Penicillin G amidases, deracemisation for amino acid synthesis, biocatalytic hydrolysis of nitriles, enzymatic and microbial hydroxylation of dienes and alpha-methyl esters, enantioselective sulphoxidations by peroxidases.

Hersteller:
Springer Verlag GmbH
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InhaltsangabeInvited Reviews.- Modelling of Enzyme Properties in Organic Solvents.- Lipase-Catalyzed Synthesis of Carboxylic Amides: Nitrogen Nucleophiles as Acyl Acceptor.- Chemoenzymatic Synthesis of Lipidated Peptides.- Chemoenzymatic Transformations in Nucleoside Chemistry.- Contributions.- Lipase-Catalyzed Regio- and Stereoselective Acylation of Hydroxy Groups in Steroid Side Chains.- Comparative Study of Substrate- and Stereospecificity of Penicillin G Amidases from Different Sources and Hybrid Isoenzymes.- Lipase-Catalyzed Resolution of Ibuprofen.- Novel Carboxyl Esterase Preparations for the Resolution of Linalyl Acetate.- Microbial and Enzymatic Synthesis of Optically Pure D- and L-3-Trimethylsilyl-alanine by Deracemization of D,L-5-Trimethylsilyl-methyl-hydantoin.- Immobilization of Rhodococcus AJ270 and Use of Entrapped Biocatalyst for the Production of Acrylic Acid.- Beauveria bassiana ATCC 7159 Contains an L-Specific ¦Á-Amino Acid Benzamidase.- Bacterial Biotransformation of Isoprene and Related Dienes.- Enantioselective Sulfoxidations Catalyzed by Horseradish Peroxidase, Manganese Peroxidase, and Myeloperoxidase.- Synthesis of Optically Active ?-Methyl ß-Hydroperoxy Esters by Diastereoselective Singlet Oxygen Ene Reaction and Horseradish Peroxidase Catalyzed Kinetic Resolution.

Invited Reviews: Modelling of Enzyme Properties in Organic Solvents (Colombo G., Ottolina G., Carrea G.); Lipase-Catalyzed Synthesis of Carboxylic Amides: Nitrogen Nucleophiles as Acyl Acceptor (van Rantwijk F., Hacking M. A. P. J., Sheldon R. A.); Chemoenzymatic Synthesis of Lipidated Peptides (Kadereit D., Waldmann H.); Chemoenzymatic Transformations in Nucleoside Chemistry (Ferrero M., Gotor V.).- Contributions: Lipase-Catalyzed Regio- and Stereoselective Acylation of Hydroxy Groups in Steroid Side Chains (Santaniello E., Ferraboschi P., Reza-Elahi S.); Comparative Study of Substrate- and Stereospecificity of Penicillin G Amidases from Different Sources and Hybrid Isoenzymes (Galunsky B., Lummer K., Kasche V.); Lipase-Catalyzed Resolution of Ibuprofen (Henke E., Schuster S., Yang H., Bornscheuer U. T.); Novel Carboxyl Esterase Preparations for the Resolution of Linalyl Acetate (Pogorevc M., Strauss U. T., Hayn M., Faber K.); Microbial and Enzymatic Synthesis of Optically Pure D- and L-3-Trimethylsilyl-alanine by Deracemization of D,L-5-Trimethylsilyl-methyl-hydantion (Pietzsch M., Waniek T., Smith R. J., Bratovanov S., Bienz S., Syldatk C.); Immobilization of Rhodococcus AJ270 and Use of Entrapped Biocatalyst for the Production of Acrylic Acid (Colby J., Snell D., Black G. W.); Beauveria bassiana ATCC 7159 Contains an L-Specific Alpha-Amino Acid Benzamidase (Holland H. L., Andreana P. R., Salehzadeh-Asl R., van Vliet A., Ihasz N. J., Brown F. M.); Bacterial Biotransformation of Isoprene and Related Dienes (Boyd D. R., Clarke D., Cleij M. C., Hamilton J. T. G., Sheldrake G. N.); Enantioselective Sulfoxidations Catalyzed by Horseradish Peroxidase, Manganese Peroxidase, and Myeloperoxidase (Tuynman A., Schoemaker H. E., Wever R.); Synthesis of Optically Active Alpha-Methyl Beta-Hydroperoxy Esters by Diastereoselective Singlet Oxygen Ene Reaction and Horseradish Peroxidase Catalyzed Kinetic Resolution (Adam W., Saha-Möller C. R., Weichold O.)