InhaltsangabePart I. Biochemical Approaches, In vitro and In vivo   1. Approaches to Detect PARP-1 Activation In vivo, In situ, and In vitro                 Girsih M. Shah, Febitha Kandan-Kulangara, Alicia Montoni, Rashmi G. Shah, Julie Brind'Amour, Momchil D. Vodenicharov, and El Bachir Affar   2. Quantification of Poly(ADP-ribose) In vitro: Determination of the (ADP-ribose) Chain Length and Branching Pattern                 Rafael Alvarez-Gonzalez and Myron K. Jacobson   3. Assay for Protein Modification by Poly-ADP-Ribose In vitro                 Opeyemi A. Olabisi and Chi-Wing Chow   4. Identification of Distinct Amino Acids as ADP-ribose Acceptor Sites by Mass Spectrometry                 Florian Rosenthal, Simon Messner, Bernd Roschitzki, Peter Gehrig, Paolo Nanni, and Micahel O. Hottiger   5. Noncovalent Protein Interaction with Poly(ADPribose)                 Maria Malanga and Felix R. Althaus   6. Noncovalent pADPr Interaction with Protein and Competition with RNA for Binding to Proteins                 Yingbiao Ji   7. Affinitybased Assays for the Identification and Quantitative Evaluation of Noncovalent Poly(ADPribose)binding Proteins                 Jean-Phillipe Gagné, Jean-François Haince, Émilie Pic, and Guy G. Poirier   8. Detecting and Quantifying pADPr In vivo                 Yi-Chen Lai, Rajesh K. Aneja, Margaret A. Satchell, and Robert S. B. Clark   9. Purification of Recombinant Poly(ADP-ribose) Polymerases                 Jean-Christophe Amé, Thomas Kalish, Françoise Dantzer, and Valérie Schreiber   10. Methods for Purification of Proteins Associated with Cellular poly(ADP-risbose) and PARP-specific Poly(ADP-ribose)                 Jennifer E. Rood, Anthony K. L. Leung, and Paul Chang   11. Purification and Characterization of Poly(ADP-ribosyl)ated DNA Replication/Repair Complexes                 Cynthia M. Simbulan-Rosenthal, Dean S. Rosenthal, and Mark E. Smulson   12. PARP1 Genomics: Chromatin Immuno-precipitation Approach using Anti-PARP1 Antibody (ChIP and ChIP-seq)                 Niraj Lodhi and Alexei V. Tulin   13. Purification of Human PARP-1 and PARP-1 Domains from E. coli for Structural and Biochemical Analysis                 Marie-France Langelier, Jamie L. Planck, Kristin M. Servent, and John M. Pascal   14. Regulation of Chromatin Structure by PARP-1                 MiYoung Kim   Part II. Genetic Manipulation Approaches   15. The Use of PARP Inhibitors in Cancer Therapy: Use as Adjuvant with Chemotherapy or Radiotherapy, Use as a Single Agent in Susceptible Patients; Techniques used to Identify Susceptible Agents                 Sydney Shall, Terry Gaymes, Farzin Farzaneh, Nicola Curtin, and Ghulam J. Mufti   16. Quantification of PARP Activity in Human Tissues: Ex vivo Assays in Blood Cells, and Immunohistochemistry in Human Biopsies                 Eszter M. Horvath, Zsuzsanna K. Zsengellér, and Csaba Szabo   17. Assay for Hypermethilation of the BRCA1 Gene Promoter in Tumor Cells to Predict Sensitivity to PARP-Inhibitor Therapy                 Ilsiya Ibragimova and Pauls Cairns   18. Generation of Poly(ADP-ribosyl)ation Deficient Mutants of the Transcription Factor, CTCF                 Dawn Farrar, Igor Chernukhin, and Elena Klenova   19. Phenotypic Characterization of Parp-1 and Parp-2 Deficient Mice and Cells                 Christian Boehler, Laurent Gauthier, Jose Yelamos, Aurélia Noll, Valérie Schreiber, and Françoise Dantzer   20. Poly(ADPribosyl)ation Pathways in Mammals: The Advantage of Murine PARG Null Mutation                 Yiran Zhou and David W. Koh   21. Genetic Approaches to Targeting Multiple PARP Genes in a Mammalian Genome                 Mirella L. Meyer-Ficca and Ralph G. Meyer   22. Approaches to Separate and Identify Poly(ADP-ribosyl)ated Proteins using PARG Knockout Drosophila                 Hiroto Nodono, Akiko Hamada, Yasuhito Kuroda, Kazuo Kamemura, Makoto Hasegawa, Toru Komiya, Machiko Kondo,

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Part I. Biochemical Approaches, In vitro and In vivo   1. Approaches to Detect PARP-1 Activation In vivo, In situ, and In vitro                 Girsih M. Shah, Febitha Kandan-Kulangara, Alicia Montoni, Rashmi G. Shah, Julie Brind¿Amour, Momchil D. Vodenicharov, and El Bachir Affar   2. Quantification of Poly(ADP-ribose) In vitro: Determination of the (ADP-ribose) Chain Length and Branching Pattern                 Rafael Alvarez-Gonzalez and Myron K. Jacobson   3. Assay for Protein Modification by Poly-ADP-Ribose In vitro                 Opeyemi A. Olabisi and Chi-Wing Chow   4. Identification of Distinct Amino Acids as ADP-ribose Acceptor Sites by Mass Spectrometry                 Florian Rosenthal, Simon Messner, Bernd Roschitzki, Peter Gehrig, Paolo Nanni, and Micahel O. Hottiger   5. Non-covalent Protein Interaction with Poly(ADP-ribose)                 Maria Malanga and Felix R. Althaus   6. Non-covalent pADPr Interaction with Protein and Competition with RNA for Binding to Proteins                 Yingbiao Ji   7. Affinity-based Assays for the Identification and Quantitative Evaluation of Non-covalent Poly(ADP-ribose)-binding Proteins                 Jean-Phillipe Gagne, Jean-Francois Haince, Emilie Pic, and Guy G. Poirier   8. Detecting and Quantifying pADPr In vivo                 Yi-Chen Lai, Rajesh K. Aneja, Margaret A. Satchell, and Robert S. B. Clark   9. Purification of Recombinant Poly(ADP-ribose) Polymerases                 Jean-Christophe Ame, Thomas Kalish, Francoise Dantzer, and Valerie Schreiber   10. Methods for Purification of Proteins Associated with Cellular poly(ADP-risbose) and PARP-specific Poly(ADP-ribose)                 Jennifer E. Rood, Anthony K. L. Leung, and Paul Chang   11. Purification and Characterization of Poly(ADP-ribosyl)ated DNA Replication/Repair Complexes                 Cynthia M. Simbulan-Rosenthal, Dean S. Rosenthal, and Mark E. Smulson   12. PARP1 Genomics: Chromatin Immuno-precipitation Approach using Anti-PARP1 Antibody (ChIP and ChIP-seq)                 Niraj Lodhi and Alexei V. Tulin   13. Purification of Human PARP-1 and PARP-1 Domains from E. coli for Structural and Biochemical Analysis                 Marie-France Langelier, Jamie L. Planck, Kristin M. Servent, and John M. Pascal   14. Regulation of Chromatin Structure by PARP-1                 MiYoung Kim   Part II. Genetic Manipulation Approaches   15. The Use of PARP Inhibitors in Cancer Therapy: Use as Adjuvant with Chemotherapy or Radiotherapy, Use as a Single Agent in Susceptible Patients; Techniques used to Identify Susceptible Agents                 Sydney Shall, Terry Gaymes, Farzin Farzaneh, Nicola Curtin, and Ghulam J. Mufti   16. Quantification of PARP Activity in Human Tissues: Ex vivo Assays in Blood Cells, and Immunohistochemistry in Human Biopsies                 Eszter M. Horvath, Zsuzsanna K. Zsengeller, and Csaba Szabo   17. Assay for Hypermethilation of the BRCA1 Gene Promoter in Tumor Cells to Predict Sensitivity to PARP-Inhibitor Therapy                 Ilsiya Ibragimova and Pauls Cairns   18. Generation of Poly(ADP-ribosyl)ation Deficient Mutants of the Transcription Factor, CTCF                 Dawn Farrar, Igor Chernukhin, and Elena Klenova   19. Phenotypic Characterization of Parp-1 and Parp-2 Deficient Mice and Cells                 Christian Boehler, Laurent Gauthier, Jose Yelamos, Aurelia Noll, Valerie Schreiber, and Francoise Dantzer   20. Poly(ADP-ribosyl)ation Pathways in Mammals: The Advantage of Murine PARG Null Mutation                 Yiran Zhou and David W. Koh   21. Genetic Approaches to Targeting Multiple PARP Genes in a Mammalian Genome                 Mirella L. Meyer-Ficca and Ralph G. Meyer   22. Approaches to Separate and Identify Poly(ADP-ribosyl)ated Proteins using PA ...