Beschreibung
The new and fully-revised volume of hematologic molecular biology for practicing and trainee hematologists
Molecular Hematology is a comprehensive resource for hematologists to increase their understanding of the molecular basis of various blood diseases, their pathogeneses, and current and emerging molecular research and therapies. The impact of molecular research on the field of hematology is significantmolecular techniques are continuing to play a central role in in the diagnosis and treatment of blood diseases. Molecular characterization of genes and proteins has increased our comprehension of the causes of hematological diseases and led to the development of new drug therapies and recombinant proteins.
Now in its fourth edition,Molecular Hematology has been thoroughly revised and updated to reflect current advances in molecular research. Chapters introduce and summarize specific disorders, such as hemophilia, anemia, and multiple myeloma, and illustrate the impact of molecular research on their diagnoses and treatments. Contributions written by respected clinicians and researchers offer accessible coverage of topics including lymphoma genetics, molecular coagulation and thrombophilia, platelet disorders, pharmacogenomics, and many others.
Demonstrates the clinical relevance of molecular biology in hematologyProvides overviews of recent advances in cancer-cell biology, with an emphasis on leukemia and lymphomaOffers new and updated chapters written by an international team of experts in the fieldPresents new full-color charts, graphs, and illustrationsIncludes access to a Wiley Companion Digital Edition providing search across the book, downloadable illustrations and notation tools
Molecular Hematology is an essential volume for both trainee and practicing hematologists and oncologists, molecular biologists, and research scientists working in the field of hematology.
Autorenportrait
DREW PROVAN, MD, FRCP, FRCPath, is Emeritus Reader in Autoimmune Haematology, Department of Haematology, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, UK.
JOHN G. GRIBBEN, MD, DSc, FRCP, FRCPath, FMedSci, is The Gordon Hamilton Fairley Professor of Medical Oncology, Barts Cancer Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, UK.
Inhalt
Contributors ix
Preface to the fourth edition xiii
Further reading xv
Acknowledgments xvi
1 Beginnings: the molecular pathology of hemoglobin 1
David Weatherall
2 Stem cells 21
David T. Scadden
3 The genetics of acute myeloid leukemias 37
Amy M. Trottier& Carolyn J. Owen
4 Molecular diagnostics and risk assessment in myeloid malignancies 49
Christian Scharenberg& Torsten Haferlach
5 Molecular basis of acute lymphoblastic leukemia 59
Bela Patel& Fiona Fernando
6 Chronic myeloid leukemia 71
Hagop Kantarjian, Jorge Cortes, Elias Jabbour& Susan OBrien
7 Myeloproliferative neoplasms 87
Jyoti Nangalia, Anthony J. Bench, Anthony R. Green& Anna L. Godfrey
8 Lymphoma genetics 101
Jennifer L. Crombie, Anthony Letai& John G. Gribben
9 The molecular biology of chronic lymphocytic leukemia 111
John G. Gribben
10 The molecular biology of multiple myeloma 121
Wee Joo Chng& P. Leif Bergsagel
11 The molecular basis of bone marrow failure syndromes and red cell enzymopathies 131
Deena Iskander, Lucio Luzzatto& Anastasios Karadimitris
12 Anemia of chronic disease 155
Tomas Ganz
13 The molecular basis of iron metabolism 161
Nancy C. Andrews& Tomas Ganz
14 Hemoglobinopathies due to structural mutations 173
D. Mark Layton& Steven Okoli
15 Molecular pathogenesis of malaria 193
David J. Roberts, Arnab Pain& Chetan E. Chitnis
16 Molecular coagulation and thrombophilia 207
Björn Dahlbäck& Andreas Hillarp
17 The molecular basis of hemophilia 221
Daniel P. Hart& Paul L.F. Giangrande
18 The molecular basis of von Willebrand disease 235
Luciano Baronciani
19 Platelet disorders 251
Kenneth J. Clemetson
20 The molecular basis of blood cell alloantigens 267
Cristina Navarrete, Louise Tilley, Winnie Chong& Colin J. Brown
21 Functions of blood group antigens 285
Jonathan S. Stamler& Marilyn J. Telen
22 Autoimmune hematological disorders 297
Drew Provan& John W. Semple
23 Molecular therapeutics in hematology: gene therapy 319
William M. McKillop& Jeffrey A. Medin
24 Pharmacogenomics 339
Leo Kager& William E. Evans
25 History and development of molecular biology 353
Paul Moss
26 Cancer stem cells 363
Sara Ali& Dominique Bonnet
27 Molecular basis of transplantation 373
Francesco Dazzi& Antonio Galleu
Index 389
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