An authoritative guide to the epidemiology, incidence, testing and diagnosis and management of HIV and AIDS.

From an international expert editor and contributor team, this new sixth edition includes expanded coverage of HIV testing, assessment and routine follow up and new chapters outlining problematic conditions associated with HIV and AIDS. Prevention strategies, early diagnosis and antiretroviral drugs and pharmacotherapy are covered in detail as well as children and women with HIV. It also addresses key psychological and mental health issues, patient perspectives and the role of patient engagement.

 As knowledge into the illness grows and major advances in HIV therapy see more people living with HIV in the community, theABC of HIV and AIDS, 6e provides clear practical guidance for general practitioners, hospital doctors, nurses, medical students, counsellors, allied health workers and anyone working and caring for patients with HIV and AIDS.

Michael W. Adler, Emeritus Professor of Genitourinary Medicine/Sexually Transmitted Diseases, University College London Medical School, London, UK;Simon G. Edwards, Consultant GU/HIV Physician, Camden Provider Services, Mortimer Market Centre, London, UK;Robert F. Miller, Professor, Reader in Clinical Infection and Honorary Consultant Physician, University College London Medical School, London, UK;Gulshan Sethi, Consultant Physician in Sexual Health and HIV, Guy's and St Thomas' NHS Foundation Trust, London, UK;Ian G. Williams, Senior Lecturer and Honorary Consultant Physician, University College London Medical School, London, UK

Contributors vii

Preface ix

1 Development of the Epidemic 1
B. Sultan and M. W. Adler

2 Immunology of HIV-1 Infection 6
M. Noursadeghi and D. Pillay

3 Viral Assays Used in the Diagnosis and Management of HIV Infection 10
A. M. Geretti and P. Vitiello

4 HIV Testing: Strategies to Prevent Late Diagnosis 15
A. Palfreeman and E. Fox

5 Clinical Staging and Natural History of Untreated HIV Infection 20
M. Tenant-Flowers and A. Mindel

6 Routine Assessment and Follow-up of the Newly Diagnosed HIV-positive Individual 25
L. Waters and D. Asboe

7 Tumours in HIV 29
M. Bower

8 The Lung and HIV 35
S. Doffman and R. F. Miller

9 HIV and Tuberculosis Co-infection 42
F. Perrin, R. Breen and M. Lipman

10 The Gut and HIV 48
B. Gazzard and M. Nelson

11 Viral Hepatitis and Liver Disease 54
R. Gilson and H. Price

12 Neurological Manifestations 59
H. Manji and R. F. Miller

13 The Eye and HIV 67
C. Younan W. Lynn and S. Lightman

14 The Skin and HIV 72
R. Morris-Jones and E. Higgins

15 The Kidney and HIV 78
J. Booth and J. Connolly

16 Sexually Transmitted Infections and HIV 83
P. French

17 Women and HIV 87
C. Wilkinson and D. Mercey

18 HIV Infection in Children 91
P. McMaster and S. Stokes

19 Antiretroviral Drugs 97
P. Benn, G. Sethi and I. G. Williams

20 Pharmacopoeia of Treatments 101
J. Minton, G. Sethi and S. G. Edwards

21 Psychological and Mental Health Issues 108
B. Hedge

22 Strategies for Preventing HIV Transmission 114
J. Imrie and G. J. Hart

23 Patient and Community Perspective 120
G. Brough and N. Lubega

24 The Role of Patient Engagement 123
C. Sandford

Index 127