With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to neurodegeneration. In Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from different yet complementary points of view. Focusing on Alzheimer's, Parkinson's, and CAG triplet repeat diseases, the authors show how studies of cellular and genetically engineered animal models have enhanced our understanding of the molecular mechanisms of neurodegenerative diseases and may lead to the development of new therapeutics. Topics include the role of Ab toxicity, glial cells, and inflammation in Alzheimer's disease; the formation of abnormal protein fragments across several diseases, the impact of dopamine and mitochondrial dysfunction on neurodegeneration; and the potential of genetics to identify the molecular mechanisms of neurodegenerative diseases. Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new therapies that prevent, delay the onset, slow the progression, or even cure these cruel diseases.

Hersteller:
Humana Press in Springer Science + Business Media
juergen.hartmann@springer.com
Heidelberger Platz 3
DE 14197 Berlin

Leseprobe

Ab Toxicity in Alzheimer''s Disease, William L. Klein. Transgenic Models of Alzheimer''s Disease, Michael C. Sugarman, Steven F. Hinton, and Frank M. LaFerla. Glial Cells in Alzheimer''s Disease, Robert E. Mrak and W. Sue T. Griffin. Inflammation in Alzheimer''s Disease, Caleb E. Finch, Valter Longo, Aya Miyao, Todd E. Morgan, Irina Rozovsky, Yubei Soong, Min Wei, Zhong Xie, and Hadi Zanjani. Proteolysis in Neurodegenerative Diseases, Vivian Y. H. Hook and Liane Mende-Mueller. Treatment Approaches for Alzheimer''s Disease, Michael Gold, Kevin M. Felsenstein, and Perry Molinoff. Tau and a-Synuclein in Neurodegenerative Diseases, Benoit I. Giasson, Christina A. Wilson, John Q. Trojanowski, and Virginia M. Y. Lee. PET Investigations of Parkinson''s Disease, Tamara Hershey, Stephen M. Moerlein, and Joel S. Perlmutter. Dopamine Neurotoxicity and Neurodegeneration, BethAnn McLaughlin. Mitochondria and Parkinson''s Disease, Russell H. Swerdlow. Pathophysiology of SCA1, Harry T. Orr and Huda Y. Zoghbi. Pathophysiology of SCA3, Puneet Opal and Henry Paulson. Pathophysiology of Spinal and Bulbar Muscular Atrophy, Diane E. Merry. Mouse Models of Huntington''s Disease, Marie-Francoise Chesselet and Michael S. Levine. Huntington-Associated Proteins, Marcy E. MacDonald, Lucius Passani, and Paige Hilditch-Maguire. Modeling Neurodegenerative Diseases in the Fruit Fly, George R. Jackson. Index.