InhaltsangabeGeneral Concepts and Basic Mechanisms.- Metabolic Concerns in Drug Design.- Role of Bioactivation in Idiosyncratic Drug Toxicity.- Michael Addition-Elimination Reactions.- Induction of Drug Metabolizing Enzymes.- Mechanism-Based Inactivation of Cytochrome P450 2A and 2B Enzymes.- CYP2E1-Biochemical and Toxicological Aspects and Role in Alcohol-Induced Liver Injury.- One and Two Electron Mediated Reduction of Quinones.- Lipoxidation-Derived Electrophiles as Biological Reactive Intermediates.- Bioactivation and Protein Modification Reactions of Unsaturated Aldehydes.- TISSUE-Specific Features And Risk Assessment Applications.- Adaptive Responses and Signal Transduction Pathways in Chemically Induced Mitochondrial Dysfunction and Cell Death.- Hepatic Bioactivation and Drug-Induced Liver Injury.- Role of Cysteine S-Conjugate ß-Lyases in the Bioactivation of Renal Toxicants.- Bioactivation of Xenobiotics in Lung: Role of CYPs and FMOs.- Generation of Reactive Metabolites and Associated DNA Adducts from Benzene, Butadiene, and Polycyclic Aromatic Hydrocarbons in Bone Marrow.- Butadiene-Mediated Mutagenesis and Carcinogenesis.- Pharmacogenetics of Drug Bioactivation Pathways.- Human Phenanthrene Metabolites as Probes for the Metabolic Activation and Detoxification of Carcinogenic Polycyclic Aromatic Hydrocarbons.

Hersteller:
Springer Verlag GmbH
juergen.hartmann@springer.com
Tiergartenstr. 17
DE 69121 Heidelberg

InhaltsangabeGeneral Concepts and Basic Mechanisms.- Metabolic Concerns in Drug Design.- Role of Bioactivation in Idiosyncratic Drug Toxicity: Structure–Toxicity Relationships.- Michael Addition–Elimination Reactions: Roles in Toxicity and Potential New Therapeutic Applications.- Induction of Drug-Metabolizing Enzymes: Contrasting Roles in Detoxification and Bioactivation of Drugs and Xenobiotics.- Mechanism-Based Inactivation of Cytochrome P450 2A and 2B Enzymes.- CYP2E1 – Biochemical and Toxicological Aspects and Role in Alcohol-Induced Liver Injury.- One- and Two-Electron-Mediated Reduction of Quinones: Enzymology and Toxicological Implications.- Lipoxidation-Derived Electrophiles as Biological Reactive Intermediates.- Bioactivation and Protein Modification Reactions of Unsaturated Aldehydes.- Tissue-Specific Features and Risk Assessment Applications.- Adaptive Responses and Signal Transduction Pathways in Chemically Induced Mitochondrial Dysfunction and Cell Death.- Hepatic Bioactivation and Drug-Induced Liver Injury.- Role of Cysteine S-Conjugate β-Lyases in the Bioactivation of Renal Toxicants.- Bioactivation of Xenobiotics in Lung: Role of CYPs and FMOs.- Generation of Reactive Metabolites and Associated DNA Adducts from Benzene, Butadiene, and PAH in Bone Marrow. Their Effects on Hematopoiesis and Impact on Human Health.- Butadiene-Mediated Mutagenesis and Carcinogenesis.- Pharmacogenetics of Drug Bioactivation Pathways.- Human Phenanthrene Metabolites as Probes for the Metabolic Activation and Detoxification of Carcinogenic Polycyclic Aromatic Hydrocarbons.

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