InhaltsangabeIntroduction.- Transport and Storage of neurotransmitters.- The neurotransmitter release machinery.- Endocytic retrieval of synaptic vesicles.- Linking the release machinery to neuronal excitation: SNARE binding to presynaptic Ca channels.- Attaching the release machinery with the synaptic cleft matrix: Ca channel interaction with laminin.- Connect the presynaptic and postsynaptic site: neurexins, neuroligins, SynCAMs, and their intracellular binding partners.- Structural and functional aspects of glutamate binding to the AMPA receptor.- The role of Stargazin and PSD95 in AMPA receptor accumulation at the postsynaptic site.- Cell biology and biochemistry of the NMDA R.- Physiology and Biophysics of Glutamate receptors.- The regulators: postsynaptic targeting of protein kinases and phosphatases.- The postsynaptic scaffolding proteins.- The postsynaptic cytoskeleton.- Synpatic plasticity: LTP and LTD.- Development of the Synapse.- Metabotropic Glutamate receptors.- The GABAergic synapse.- The glycinergic synapse.- Postsynaptic ion channels (SK K channels, which regulate NMDA receptor activity, Ca channels.- Stroke: Excitotoxicity by glutamate.- Synaptic contributions to epilepsy.- Huntington's and related polyglutamine expansion diseases and their effect on the synapse.- Dysregulation of synaptic function in Alzheimer's disease.- The role of synaptic alterations in chronic pain.- Autism from a synaptic perspective.- Anxiety disorders.- Depression.- Schizophrenia.

Hersteller:
Springer Verlag GmbH
juergen.hartmann@springer.com
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Leseprobe

Introduction.- Transport and Storage of neurotransmitters.- The neurotransmitter release machinery.- Endocytic retrieval of synaptic vesicles.- Linking the release machinery to neuronal excitation: SNARE binding to presynaptic Ca channels.- Attaching the release machinery with the synaptic cleft matrix: Ca channel interaction with laminin.- Connect the presynaptic and postsynaptic site: neurexins, neuroligins, SynCAMs, and their intracellular binding partners.- Structural and functional aspects of glutamate binding to the AMPA receptor.- The role of Stargazin and PSD95 in AMPA receptor accumulation at the postsynaptic site.- Cell biology and biochemistry of the NMDA R.- Physiology and Biophysics of Glutamate receptors.- The regulators: postsynaptic targeting of protein kinases and phosphatases.- The postsynaptic scaffolding proteins.- The postsynaptic cytoskeleton.- Synpatic plasticity: LTP and LTD.- Development of the Synapse.- Metabotropic Glutamate receptors.- The GABAergic synapse.- The glycinergic synapse.- Postsynaptic ion channels (SK K channels, which regulate NMDA receptor activity, Ca channels.- Stroke: Excitotoxicity by glutamate.- Synaptic contributions to epilepsy.- Huntington¿s and related polyglutamine expansion diseases and their effect on the synapse.- Dysregulation of synaptic function in Alzheimer¿s disease.- The role of synaptic alterations in chronic pain.- Autism from a synaptic perspective.- Anxiety disorders.- Depression.- Schizophrenia.